Unlock The Fountain Of Youth With These NAD+ Supplements
Are you looking to stay young forever?
Nicotinamide adenine dinucleotide (NAD+) supplements help give our cells the power they need to reduce inflammation, fight off disease, strengthen resilience against stressors, enhance cognitive ability, and improve mitochondrial health - important components of anti-aging. With the natural production of NAD+ decreasing over time, these supplements are essential to staying healthy as you age.
An NAD+ supplement can unlock potential anti-aging benefits and help you feel more energized and healthy regardless of age. In this blog post, we'll explore some of the best NAD+ supplements available.
My Selection Process
I have been on the hunt for a trustworthy NAD+ supplement. I have carefully researched each selection and found the best NAD+ supplements, giving you peace of mind that all brands have undergone strict examination to guarantee potency and have been tested for harmful contaminants like heavy metals and microbes. Continue reading to find out which ones made it into the list of my top picks!
Elysium Basis NAD+
Best for maintaining healthy DNA and increasing cellular energy.
Why I Dig It
Developed by Elysium chief scientist and renowned aging researcher Leonard Guarente, Ph.D., Elysium Basis NAD+ is the revolutionary new way to fight against the visible signs and side effects of aging. Taking two capsules of this powerful new supplement every morning can increase and sustain NAD+ levels in your body and promote healthy aging.
Benefits include reducing general tiredness and fatigue, fighting cellular aging to protect your DNA from stressors, supporting collagen and ceramide synthesis for healthy skin, and promoting healthy muscle function.
This product contains two potent ingredients to help combat the battle against time; nicotinamide riboside (NR) and pterostilbene, a natural dietary compound and the primary antioxidant component of blueberries. Each serving contains 250 mg of crystalline NR and 50 mg of pterostilbene. Plus, these vegan, gluten-free, nut-free, non-GMO capsules can be taken with or without food.
The Data Dump
Elysium is an innovative supplement company that has been rigorously tested to ensure purity and quality. All of Elysium's products are third-party tested, with testing done on heavy metals, solvents, mold, and yeast. You can even view individual Certificates of Analysis for each product online.
In a published article in 2017, Elysium Basis NAD+ was clinically proven to increase NAD+ levels by an average of 40% in a double-blind, randomized, placebo-controlled clinical trial. This study was published in the peer-reviewed journal Nature Partner Journals: Aging and Mechanisms of Disease.
Furthermore, Elysium holds the distinction of being NSF Certified for Sport — the only third-party certification program that the U.S. Anti-Doping Agency recognizes. When you choose Elysium, you can rest assured that it contains no unsafe contaminants or prohibited substances and will not mask any potential drugs in your system. With Elysium's dedication to excellence and rigorous testing standards, you can trust that Elysium Basis NAD+ has your best interest at heart.
RENUE Lipo NAD+ Complete
Best for DNA repair and healthy aging.
Why I Dig It
RENUE Lipo NAD+ Complete, is a revolutionary 3-in-1 NAD+ boosting supplement featuring proprietary liposomes that protect from digestive enzymes and allows for the ingredients to be absorbed and utilized rather than being destroyed in the stomach. With increased NAD+, nicotinamide mononucleotide (NMN), and NR levels in one powerful hit, this product is scientifically proven to keep your body's NAD+ levels elevated.
Each serving delivers 250 mg of beta-NMN, 190 mg of NAD+, and 160 mg of NR. Plus, with no artificial colors, flavors, or preservatives, it is non-GMO and suitable for vegans – delivering maximum results without compromising quality.
RENUE Lipo NAD+ Complete can help foster restored energy levels and optimized mental clarity, cellular energy production, and cell metabolism.
The Data Dump
RENUE is a trusted and reliable supplement company specializing in NAD+ supplements. Their formulas have been created with great attention to detail, undergoing three rounds of rigorous testing for purity, potency, safety, and quality by both internal and third-party laboratories. They test each product for heavy metals and other microbial contaminants.
To further establish trust in this product, the manufacturing facility is Good Manufacturing Practice certified by NSF International, and all products are processed, tested, and packaged in the United States.
RENUE offers a Certificate of Analysis that can be viewed online under your batch number to provide true transparency to customers. So if you're looking for a reliable, trustworthy product of superior quality that gives you the desired results, RENUE Lipo NAD+ Complete is your go-to supplement.
Tru Niagen
Best for vitality, muscle health, and healthy aging.
Why I Dig It
Tru Niagen is the only patented form of NR on the market. This efficient NAD+ boosting supplement is backed by 30+ owned and licensed patents, 200+ published scientific studies, and two Nobel Prize winners. It is designed to help you reach your goals faster by increasing your NAD+ levels naturally and supporting your immune system, maintaining healthy mitochondria, and improving muscle and cell function.
Tru Niagen contains 300 mg of NR chloride in each serving. The vegetarian capsules are formulated without gluten or nuts and does not include caffeine, animal by-products, artificial colors, or flavors. With regular usage, your NAD+ levels can be increased by approximately 40-50% after 8 weeks, making it one of the most effective supplements that aim to bring lasting changes through natural methods.
If you're looking for a way to boost your NAD+ levels and reap its numerous anti-aging benefits, look no further than Tru Niagen — it's clinically proven to get you fast results. This innovative formula will offer you improved cell function and energy.
The Data Dump
Tru Niagen stands apart from other supplement companies due to their uncompromising commitment to delivering high-quality products. Their stringent manufacturing process subjects its products to 36 tests, far more than the industry standard, ensuring that every batch meets regulations related to Good Manufacturing Practices (GMP) set by the FDA.
Each batch of Tru Niagen is tested for efficacy, purity, safety, and heavy metals by internal laboratories located in Longmont, Colorado, and third-party labs approved by ChromaDex and is ISO/IEC 17025:2017 accredited. You can request a Certificate of Analysis by providing your LOT number for your purchased product.
Tru Niagen also pursues additional certifications beyond GMP standards with NSF International. This certificate confirms that all ingredients listed on the label can be accounted for in their product and meet purity standards and banned substance protocols. Their dedication to quality control procedures sets them apart from competitors and assures Tru Niagen users receive premium-grade supplements free of contaminants and undesirable substances.
A 2019 study examined Niagen's oral availability and safety in overweight healthy men and women in an 8-week randomized, double-blind, placebo-controlled clinical trial. Participants consumed 100, 300, and 1000 mg of Niagen. They concluded that whole blood NAD+ and other NAD+ metabolites significantly increased within 2 weeks.
Thorne NiaCel 400
Best for cellular energy production and healthy aging.
Why I Dig It
Thorne NiaCel 400 is a powerful NAD+ supplement designed to help you feel younger and stay healthy. Featuring 415 mg of NR, it can help your body quickly produce NAD+, an essential chemical that helps promote optimal health. With regular use of this supplement, you can benefit from increased cellular energy production, improved athletic performance, and lean body composition.
Fitness enthusiasts can also take advantage of this product. Research has shown that NiaCel 400 helps improve exercise efficiency, allowing them to reach their health and fitness goals while preserving optimal health. And those with dietary sensitivities can rest easy — this supplement is gluten-free, dairy-free, and vegan!
The Data Dump
Thorne NiaCel 400 is a cutting-edge dietary supplement that meets the highest quality standards. It is developed with extensive testing performed on all raw materials at each stage in the production process, ensuring you receive only the purest and most potent ingredients from start to finish. This superior level of testing includes four rounds.
During these tests, each raw material is carefully analyzed for identity, quality, purity, and potency. Subsequently, Thorne adds an additional layer of safety by rigorously testing all finished products for stability, microbial contaminants, pesticide residues, and heavy metals.
Throne does not currently release Certificates of Analysis (CoA). However, be on the lookout as they are getting CoA's published on their website, which will likely happen in 2023. With such meticulous scrutiny on every step of production providing assurance of exceptional quality and protection, you can rest assured that Thorne NiaCel 400 is a safe and reliable dietary supplement.
Designs for Health Mito-NR
Best for mitochondrial cell support.
Why I Dig It
Designs for Health Mito-NR offers powerful cellular support with clinically relevant amounts of Niagen. By taking this supplement, you can be sure your cells get the nutrients needed to stay healthy. The formula contains 300 mg of Niagen, an essential nutrient that helps cells utilize energy within the mitochondria, 200 mg of CoQ10 and geranylgeraniol.
The addition of geranylgeraniol — sourced from the Annatto plant — makes this supplement unique. This molecule plays an essential role in protein synthesis and CoQ10 production, which are necessary for supporting healthy aging. Taking Mito-NR regularly may give you the boost you need to keep your cells functioning optimally.
Adding to its quality formulation, Designs for Health Mito-NR is completely vegan and free of GMOs, gluten, soy, and all animal products.
The Data Dump
Designs for Health is an exceptional supplement company that has been developed with extreme attention to detail and care. All ingredients are rigorously sourced, developed, and tested to ensure purity, strength, and quality. They adhere to the FDA Good Manufacturing Practices and utilize third-party testing to guarantee the product satisfies the highest standards.
Additionally, all products are tested for pesticides, heavy metals, and microbiological organisms. Furthermore, Certificates of Analysis can be requested from Designs for Health.
Benefits of NAD Supplementation
Nicotinamide adenine dinucleotide, or NAD+, is a coenzyme found in every living cell of the human body. It plays a critical role in cellular energy metabolism and energy production, making it an essential compound for optimal health and normal cellular function. Also known as NAD+ in its oxidized state and NADH in its reduced form, NAD+ is naturally produced in the body. However, aging can deplete NAD+ levels, leading to various health concerns and age-related diseases. We will explore the potential health benefits of NAD+ supplements for overall health and well-being.
Protect Against Cellular Damage
NAD+ is essential for the repair of damaged DNA and the regulation of cell survival pathways. Supplementing with NAD+ can help protect against cellular damage caused by environmental factors such as UV radiation and exposure to toxins. It can also slow the natural aging process by preserving cellular health and preventing cell death. A 2015 study proposes that NAD+ boosters combined with chemotherapeutic drugs used for treating liver cancer, might be helpful in protecting healthy cells against DNA damage and mutation into cancerous cells.
Decrease the Risk of Cardiovascular Disease
A study examined the oral administration of NMN supplements for 12 weeks in middle-aged participants. The study concluded that 250 mg/day of the NAD+ precursor, NMN, safely and effectively elevated NAD+ metabolism in healthy middle-aged adults. Additionally, NMN supplementation could decrease the risk of developing cardiovascular disease (i.e., hypertension, elevated cholesterol levels, and arterial stiffness).
A 2023 study examined overweight or obese middle-aged and older adults. The researchers concluded that 28 days of NAD+ supplementation safely increased NAD+ levels and significantly reduced body weight, total LDL and non-HDL cholesterol, and diastolic blood pressure. These data provide more information regarding the many benefits of NAD+ and improved cardiometabolic outcomes in older adults.
Combat Age-Related Cogntive Decline
As we age, the levels of NAD+ in our bodies decline. This decline can lead to various age-related health concerns, such as cognitive decline and increased susceptibility to chronic diseases. NAD+ supplements may promote cognitive health and protect against Alzheimer's disease. Taking an oral supplement can help counteract this decline by stimulating cellular repair, supporting a healthy aging process, and reducing inflammation.
In conclusion, NAD+ supplements are a promising solution for many health concerns. By boosting cellular metabolism, protecting against cellular damage, and combating age-related cognitive decline, an NAD+ supplement can offer an array of benefits for overall health and well-being as you age. If you're looking to optimize your cellular health and feel your best, an NAD+ supplement is worth considering.
NAD+ FAQs
NAD+ supplements have been gaining popularity lately; however, it is important to understand the benefits before making a decision. I'm here to equip you with all the facts so that you can make an informed choice about whether these dietary supplements suit your health goals!
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When choosing the best NAD+ supplement, it is vital to understand the various forms and what benefits each can provide. The two most common forms are the NAD+ precursors, nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN).
NR supplements have become one of the most widely researched NAD+ precursors; NR is a form of vitamin B3. Taking an NR supplement can elevate NAD+ levels in the body and has shown to be effective in treating cardiovascular, neurodegenerative, and metabolic disorders.
Additionally, an NMN supplement can be rapidly absorbed and converted to NAD+. Numerous studies have shown that an NMN supplement can increase NAD+ production, enhance insulin secretion, improve mitochondrial function, and improve neuronal function in the brain.
Given these differences between the two forms, currently, there is no single answer for which type of NAD+ precursor is best. More research is needed; however, some research has revealed that both forms, when combined, may be beneficial in boosting NAD+ levels and improving overall health. -
Yes, NAD+ supplements can be very effective. More and more research has been published in the last few years to support the efficacy of NAD+ supplements. Some health benefits include increased energy levels, improved cognitive function, and mental clarity, better cell health and metabolism, heightened antioxidant protection from oxidative stress, strengthened immune system, improved cardiometabolic outcomes, and DNA repair.
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Yes, it is generally safe to take NAD+ daily. Long-term use of an NAD+ supplement has been shown to be effective. The recommended dosage typically consists of 100 mg - 250 mg per day. However, a 2018 study concluded that chronic supplementation of 1,000 mg per day of an NR supplement is well-tolerated and effective.
Studies have shown that regular NAD+ supplementation can improve metabolism, promote cellular repair, and improved mitochondrial function. Additionally, NAD+ has several other potential benefits, such as acting as an antioxidant by neutralizing harmful free radicals in the body. -
The time it takes for NAD+ to start working largely depends on the individual and their current health status. Generally, if you are deficient in NAD+ levels—which can occur due to aging, poor nutrition, or being sedentary—you may experience benefits within days or weeks. In fact, one study found that NAD+ metabolites were higher after 8 days of NMN supplementation in obese and overweight adults. While others have shown that a 6 week intervention effectively stimulated NAD+ metabolism in healthy middle-aged and older adults.
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Taking an NAD+ supplement can offer various benefits, but it is important to understand the potential side effects before taking this supplement. The most commonly reported side effects include nausea, diarrhea, hot flashes, rashes, and leg cramps. Overall, taking NAD+ supplements is well-tolerated, and these side effects rarely occur in human clinical trials. Additionally, women who are pregnant or nursing should not take an NAD+ supplement without first consulting with your doctor.
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NAD+ supplementation may have beneficial effects for slowing down aging at a cellular level and is an exciting therapy that may promote longevity. NAD+ is an essential coenzyme critical in DNA repair, inflammation inhibition, and improved cell stress-handling capabilities. Furthermore, it increases brain connections to combat the age-related decline, optimizes the functionality of mitochondria inside our bodies that generate most of the body's energy supply, and regulates circadian rhythm - all integral parts of longevity.
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If you want to boost NAD+ levels naturally you may want to consider a few easy lifestyle changes.
Caloric restriction increases NAD+ levels while lowering NADH levels and activating sirtuins. Sirtuins are signaling proteins that detect low energy levels within the cell, provoking physiological changes relevant to health and longevity. Specifically, sirtuins are critical players in the health of our mitochondria and are essential in repairing DNA, lowering inflammation and oxidative stress, and improving metabolism and cellular energy production.
Besides caloric restriction, NAD+ levels can be increased with meat, fish, and dairy products. Maintaining a healthy diet by consuming avocados, broccoli, mushrooms, and nuts are great natural sources of vitamin B3 that can also boost NAD+ levels. Ingestion of the amino acid tryptophan or forms of vitamin B3 (niacin, nicotinic acid, niacinamide) stimulates the formation of NAD+.
Another option is to add a supplement containing NR and/or NMN to your daily routine, which can help boost NAD+ levels. This compound is known as an "anti-aging" compound that has been proven to increase the production of NAD+ in the body.
Other lifestyle changes worth considering when raising your NAD+ levels include reducing stress, avoiding alcohol consumption, and getting regular physical activity such as strength training or aerobic exercises like running or cycling. Physical activity positively correlates with elevated NAD+ levels in the muscle of older adults. In other words, the more you exercise and/or move your body, the greater your NAD+ levels leading to healthy aging.
The Recap
With plenty of supplements on the market, making an educated decision regarding your purchase can be difficult. Luckily, this blog post has everything you need to know when shopping for an NAD+ supplement. Thanks for taking the time to read about the best NAD+ supplement for cellular health! To help you make a well-informed choice about which supplement is right for you, check out my top picks.
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